The recent (re) discovery of the meningeal lymphatic system has opened new theories as to
how immune cells traffic and interact with the central nervous system (CNS). While evidence …

At steady state, the CNS parenchyma has few to no lymphocytes and less potent Ag-
presentation capability compared with other organs. However, the meninges surrounding …

Highlights•Meninges are an immunologically active compartment regulating normal and
pathological brain function.•The extended meningeal lymphatics network ensures drainage …

The central nervous system (CNS) was previously thought to lack lymphatics and shielded
from the free diffusion of molecular and cellular components by the blood–brain barrier …

In recent decades there has been a large focus on understanding the mechanisms of
peripheral immune cell infiltration into the central nervous system (CNS) in …

Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …

Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …

Ongoing research is revealing multiple, previously unappreciated, facets of immunity in the
central nervous system, and the recent studies on the meningeal lymphatic system represent …

The many interactions between the nervous and the immune systems, which are active in
both physiological and pathological states, have recently become more clearly delineated …

Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …