The vascular system is integral for maintaining organ‐specific functions and homeostasis.
Dysregulation in vascular architecture and function can lead to various chronic or acute …

The vascular mechanical microenvironment consists of a mixture of spatially and temporally
changing mechanical forces. This exposes vascular endothelial cells to both hemodynamic …

The paradigm of regenerative medicine has recently shifted from in vitro to in situ tissue
engineering: implanting a cell-free, biodegradable, off-the-shelf available scaffold and …

In vivo, cells of the vascular system are subjected to various mechanical stimuli and have
demonstrated the ability to adapt their behavior via mechanotransduction. Recent advances …

Cells in the cardiovascular system are constantly exposed to complex mechanical
stimulation due to the pulsatile nature of blood flow and the haemodynamic forces that are …

Highlights•Environmental and cell-generated forces profoundly influence endothelial
behavior.•Novel mechanosensory mechanisms provide insight into an endothelial force …

Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Blood vessel chips are bioengineered microdevices, consisting of biomaterials, human cells,
and microstructures, which recapitulate essential vascular structure and physiology and …

Hemodynamics play a central role in the health and disease of the coronary and peripheral
vascular systems. Vessel-lining endothelial cells are known mechanosensors, responding to …

The action of mechanical forces on blood vessels has been for long time uniquely
associated to the effects elicited by the blood flow sensed at the free surface of endothelial …