Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity

DR Seals, JN Justice, TJ LaRocca - The Journal of physiology, 2016 - Wiley Online Library
Most nations of the world are undergoing rapid and dramatic population ageing, which
presents great socio‐economic challenges, as well as opportunities, for individuals, families …

[HTML][HTML] Translational geroscience: emphasizing function to achieve optimal longevity

DR Seals, S Melov - Aging (albany NY), 2014 - ncbi.nlm.nih.gov
Among individuals, biological aging leads to cellular and organismal dysfunction and an
increased risk of chronic degenerative diseases and disability. This sequence of events in …

The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span

F Sierra - Cold Spring Harbor perspectives in …, 2016 - perspectivesinmedicine.cshlp.org
Research on the biology of aging has accelerated rapidly in the last two decades. It is now at
the point where translation of the findings into useful approaches to improve the health of the …

Advances in geroscience: impact on healthspan and chronic disease

JB Burch, AD Augustine, LA Frieden… - … Series A: Biomedical …, 2014 - academic.oup.com
Population aging is unprecedented, without parallel in human history, and the 21st century
will witness even more rapid aging than did the century just past. Improvements in public …

Healthy aging: the ultimate preventative medicine

M Kaeberlein, PS Rabinovitch, GM Martin - Science, 2015 - science.org
Age is the greatest risk factor for nearly every major cause of mortality in developed nations.
Despite this, most biomedical research focuses on individual disease processes without …

New horizons: novel approaches to enhance healthspan through targeting cellular senescence and related aging mechanisms

T Tchkonia, AK Palmer… - The Journal of Clinical …, 2021 - academic.oup.com
The elderly population is increasing faster than other segments of the population throughout
the world. Age is the leading predictor for most chronic diseases and disorders …

A gerophysiology perspective on healthy ageing

PH Kemoun, I Ader, V Planat-Benard, C Dray… - Ageing research …, 2022 - Elsevier
Improvements in public health and health care have resulted in significant increases in
lifespan globally, but also in a significant increase in chronic disease prevalence. This has …

Extending human healthspan and longevity: a symposium report

LM DeVito, N Barzilai, AM Cuervo… - Annals of the New …, 2022 - Wiley Online Library
For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …

Are we ill because we age?

T Fulop, A Larbi, A Khalil, AA Cohen… - Frontiers in …, 2019 - frontiersin.org
Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an
increasingly serious health and socioeconomic concern for modern societies. Science has …

Moving geroscience from the bench to clinical care and health policy

F Sierra, A Caspi, RH Fortinsky… - Journal of the …, 2021 - Wiley Online Library
Geriatricians and others must embrace the emerging field of geroscience. Until recently
geroscience research was pursued in laboratory animals, but now this field requires …