Various products containing sinomenine monomer and extracts of Sinomenium acutum
have been widely applied in clinical treatments. The goal of the present study was to …

Sinomenine, an alkaloid derived from the Chinese medical plant Sinomenium acutum, was
studied with regard to its pharmacokinetics and tissue distribution in rats, and to its protein …

Objective To study pharmacokinetic parameters and absolute bioavailability for oral use of
sinomenine tablet in beagle dogs. Method Applying to double cycle self crossover design, a …

Aim: To improve and validate analytical methods based on HPLC and liquid
chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI …

AIM To investigate the relationship between sinomenine distribution and its organic
toxicology in rats so as to give some pharmacological data for clinical application of …

A sensitive and selective liquid chromatographic tandem mass spectrometric method was
developed and validated for the determination of sinomenine in human plasma. Plasma …

Sinomenine is an active substance extracted from the traditional Chinese medicine
Sinomenium acutum. Sinomenine has been shown to mediate a wide range of …

Abstract Sinomenine (7, 8‐didehydro‐4‐hydroxy‐3, 7‐dimethoxy‐17‐methylmorphinan‐6‐
one) is a pure alkaloid extracted from the Chinese medical plant. In this report a liquid …

Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium
acutum (Thunb.) Rehd. et Wils which exhibits significant analgesic, anti-inflammatory, and …

Sinomenine is an active ingredient extracted from herb medicine, which has been
prescribed to treat rheumatoid arthritis in clinics. The present work was to develop a simple …