Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …

The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …

Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …

HLA-DM catalyzes peptide dissociation and exchange in class II MHC molecules through a
mechanism that has been proposed to involve the disruption of specific components of the …

During maturation of MHC II molecules, newly synthesized and assembled complexes of
MHC II αβ dimers with invariant chain (Ii) are targeted to endosomes, where Ii is proteolyzed …

Abstract HLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound
peptides in endocytic compartments and stabilizes empty MHCII molecules. Crystal …

Human histocompatibility leukocyte antigen (HLA)-DM is a facilitator of antigen presentation
via major histocompatibility complex (MHC) class II molecules. In the absence of HLA-DM …

Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …

HLA-DR molecules associated with class II—associated invariant chain peptides (CLIP) are
generated in vivo as an intermediate in class II maturation. Such complexes can be …

Abstract HLA-DM (abbreviated DM) is an MHC-encoded glycoprotein that catalyzes the
selective release of peptides, including class II-associated invariant chain peptides, from …