The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Aims Atherosclerosis is characterized by the abundant infiltration of myeloid cells starting at
early stages of disease. Myeloid cells are key players in vascular immunity during …

Rationale: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of
pro-and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional …

Atherosclerosis is a chronic inflammatory process of medium and large size vessels that is
characterized by the formation of plaques consisting of foam cells, immune cells, vascular …

Aims Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic
cells (DCs)] in the vessel wall is a hallmark of atherosclerosis. Using integrated single-cell …

Atherosclerosis continues to be the leading cause of cardiovascular disease. Development
of atherosclerosis depends on chronic inflammation in the aorta and multiple immune cells …

Rationale: It is assumed that atherosclerotic arteries contain several macrophage subsets
endowed with specific functions. The precise identity of these subsets is poorly …

Atherosclerotic lesion-related thrombosis is the major cause of myocardial infarction and
stroke, which together constitute the leading cause of mortality worldwide. The inflammatory …

Lymphocytes are prominent components of human atherosclerotic lesions, but their
presence in murine models of disease has not been confirmed. Lymphocyte subpopulations …

Inflammation plays a key role in the initiation and progression of atherosclerosis and can be
caused by multiple agents, including increased concentration of circulating low-density …