[HTML][HTML] Role of the IL-23/IL-17 axis in psoriasis and psoriatic arthritis: the clinical importance of its divergence in skin and joints

MA Boutet, A Nerviani, G Gallo Afflitto… - International journal of …, 2018 - mdpi.com
Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …

[HTML][HTML] Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies

NC Brembilla, WH Boehncke - Frontiers in Immunology, 2023 - frontiersin.org
Psoriasis is a common chronic inflammatory skin disease, associated with substantial
comorbidity. TH17 lymphocytes, differentiating under the influence of dendritic cell-derived …

[HTML][HTML] The IL-17/IL-23 axis and its genetic contribution to psoriatic arthritis

M Vecellio, VX Hake, C Davidson, MC Carena… - Frontiers in …, 2021 - frontiersin.org
Psoriatic arthritis (PsA) is a chronic inflammatory disease belonging to the family of
spondyloarthropathies (SpA). PsA commonly aggravates psoriasis of the skin and frequently …

Anti‐IL‐23 and Anti‐IL‐17 biologic agents for the treatment of immune‐mediated inflammatory conditions

J Frieder, D Kivelevitch, I Haugh… - Clinical …, 2018 - Wiley Online Library
Advancements in the immunopathogenesis of psoriasis have identified interleukin (IL)‐23
and IL‐17 as fundamental contributors in the immune pathways of the disease. Leveraging …

[HTML][HTML] The IL-17 family of cytokines in psoriasis: IL-17A and beyond

NC Brembilla, L Senra, WH Boehncke - Frontiers in immunology, 2018 - frontiersin.org
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major
global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been …

The role of IL‐23 and the IL‐23/TH17 immune axis in the pathogenesis and treatment of psoriasis

G Girolomoni, R Strohal, L Puig… - Journal of the …, 2017 - Wiley Online Library
Psoriasis is a chronic, immune‐mediated disease affecting more than 100 million people
worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to …

Shifting the focus–the primary role of IL‐23 in psoriasis and other inflammatory disorders

MJ Gooderham, KA Papp… - Journal of the European …, 2018 - Wiley Online Library
Insights into the pathophysiology of autoimmune inflammatory diseases including psoriasis
have advanced considerably in recent years, and in parallel, so too have the available …

Cytokines of the IL‐17 family in psoriasis

F Lauffer, K Eyerich, WH Boehncke… - JDDG: Journal der …, 2020 - Wiley Online Library
Various immune cells and their messenger substances influence the development of
psoriasis. Cytokines of the IL‐17 family are of particular importance. In addition to IL‐17A …

[HTML][HTML] The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis

A Blauvelt, A Chiricozzi - Clinical reviews in allergy & immunology, 2018 - Springer
Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …

[HTML][HTML] The IL-23/IL-17 pathway in inflammatory skin diseases: from bench to bedside

T Liu, S Li, S Ying, S Tang, Y Ding, Y Li, J Qiao… - Frontiers in …, 2020 - frontiersin.org
Interleukin-17 (IL-17) is an essential proinflammatory cytokine, which is mainly secreted by
the CD4+ helper T cells (Th17 cells) and subsets of innate lymphoid cells. IL-17A is …