Inflammatory responses are fundamental protective warning mechanisms. However, in
certain instances, they contribute significantly to the development of several chronic …

On the basis of the previously reported polypharmacological profile of truncated d-1′-
homologated adenosine derivatives [J. Med. Chem. 2020, 63, 16012], the l-nucleoside …

Background: Since the anti-inflammatory activity of arachidonic acid derivatives was
previously reported, we synthesized three new amide derivatives of arachidonic acid (AA …

Inhibitory oligodeoxynucleotides (ODNs) are short single-stranded DNA, which capable of
folding into complex structures, enabling them to bind to a large variety of targets. With …

Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert
biological effects in vitro and in vivo via selective covalent modification of thiol-containing …

Deazadenosine (3-DA) is a general methylation inhibitor that depletes S-
adenosylmethionine, a methyl donor, by blocking S-adenosylhomocysteine hydrolase …

Adenosine (ADO) and its structurally related analogues are known to regulate the activities
of immune and inflammatory cells, including a number of key functions of mononuclear …

In this work, three series of ω-3 polyunsaturated fatty acid-alkanolamine derivatives (PUFA-
AAs) were synthesized, characterized and their anti-inflammatory activity in vivo was …

Docosahexaenoic acid (DHA) has a strong anti-inflammatory effect and is reported to bind to
the ligand-binding domain (LBD) of the anti-inflammatory modulator Nur77. Recently, we …

We describe herein the preparation of certain 2-substituted 3-arylquinoline derivatives and
the evaluation of their anti-inflammatory effects in LPS-activated murine J774A. 1 …