The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

It has become a current social trend for women to delay childbearing. However, the quality of
oocytes from older females is compromised and the pregnancy rate of older women is lower …

In recent years, postponement of marriage and childbearing in women of reproductive age
has led to an increase in the incidence of age-related infertility. The reproductive aging …

Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

BACKGROUND In humans, normal healthy children are regularly produced through
fertilization of fresh oocytes with fresh spermatozoa. However, asynchrony between oocytes …

It is well known that maternal ageing not only causes increased spontaneous abortion and
reduced fertility, but it is also a high genetic disease risk. Although assisted reproductive …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

The widespread use of a variety of assisted reproductive technologies has removed many of
the constraints that previously restricted mammalian reproduction to the period between …

It is well known that female reproduction ability decreases during the forth decade of life due
to age-related changes in oocyte quality and quantity; although the number of women trying …

Optimal maturation of the oocyte depends on its environment and determines embryo
competence, because the embryonic genome is not active until the cleavage stage and new …