Inflammatory fibrosis is a characteristic feature of myocarditis, dilated cardiomyopathy
(DCM), and congestive heart failure. Th1-type immune responses, mediated by interleukin …

Th1-type immune responses, mediated by IL-12-induced IFN-γ, are believed to exacerbate
certain autoimmune diseases. We recently found that signaling via IL-12Rβ1 increases …

We report here that interleukin (IL)-13 protects BALB/c mice from myocarditis, whether
induced by peptide immunization or by viral infection. In contrast to mild disease in IL-4 …

IL-12 and IFN-γ positively regulate each other and type 1 inflammatory responses, which are
believed to cause tissue damage in autoimmune diseases. We investigated the role of the IL …

Inflammation has been recognized increasingly as a critical pathologic component of a
number of heart diseases. A mouse model of autoimmune myocarditis was developed to …

Increased levels of interleukin-6 (IL-6) have been observed in patients with acute
myocarditis and are associated with poor prognosis. This study was designed to examine …

Background—Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-
helper (Th) 1 responses. This effect is believed to be mediated primarily through the …

Background—Interferon-γ (IFN-γ) is an essential cytokine in the regulation of inflammatory
responses in autoimmune diseases. Little is known about its role in inflammatory heart …

Chronic heart failure is associated with an activation of the immune system characterized
among other factors by the cardiac synthesis and serum expression of proinflammatory …

Ongoing coxsackievirus B3 (CVB3) myocarditis is characterized by persistence of viral RNA
and chronic inflammation primarily mediated by macrophages and T cells. Activated …