Aims Direct cardiac reprogramming represents an attractive way to reversing heart damage
caused by myocardial infarction because it removes fibroblasts, while also generating new …

Background After myocardial infarction, the lost myocardium is replaced by fibrotic tissue,
eventually progressively leading to myocardial dysfunction. Direct reprogramming of …

Background: Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells in
situ represents a promising strategy for cardiac regeneration. A combination of 3 cardiac …

Background: Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged
as a promising strategy to remuscularize injured myocardium. However, it is insufficient to …

The adult human heart has limited regenerative capacity. As such, the massive
cardiomyocyte loss due to myocardial infarction leads to scar formation and adverse cardiac …

Direct conversion of fibroblasts into induced cardiomyocytes (iCMs) holds promising
potential to generate functional cardiomyocytes for drug development and clinical …

The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac
function after insult; thus, the ability to regenerate and repair the injured myocardium …

Transient overexpression of defined combinations of master regulator genes can effectively
induce cellular reprogramming: the acquisition of an alternative predicted phenotype from a …

Direct cardiac reprogramming has emerged as a novel therapeutic approach to treat and
regenerate injured hearts through the direct conversion of fibroblasts into cardiac cells. Most …

Cardiac disease remains a major cause of death worldwide. Direct cardiac reprogramming
has emerged as a promising approach for cardiac regenerative therapy. After the discovery …