Prospective Study of Urinary Prostaglandin E2 Metabolite and Colorectal Cancer Risk
Purpose Overexpression of cyclooxygenase-2 (COX-2) has been shown to play a major role
in colorectal cancer pathogenesis. However, no human study has directly investigated …
in colorectal cancer pathogenesis. However, no human study has directly investigated …
Urinary prostaglandin E2 metabolite and risk for colorectal adenoma
COX-2 is upregulated in most colorectal cancers. Most of the COX-2 tumor–inducing effects
are believed to be mediated through overproduction of prostaglandin E2 (PGE2), which can …
are believed to be mediated through overproduction of prostaglandin E2 (PGE2), which can …
Urine PGE-M: a metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia
JC Johnson, CR Schmidt, MJ Shrubsole… - Clinical …, 2006 - Elsevier
Background & Aims The enzyme cyclooxygenase-2 is expressed in a majority of colorectal
carcinomas (CRCs) and is important in prostaglandin production. We have developed an …
carcinomas (CRCs) and is important in prostaglandin production. We have developed an …
Differential expression of cyclooxygenase 2 in human colorectal cancer
J Dimberg, A Samuelsson, A Hugander, P Söderkvist - Gut, 1999 - gut.bmj.com
BACKGROUND Experimental, clinical, and epidemiological studies have implicated
mitogenic metabolites of arachidonic acid such as prostaglandin E2 (PGE2) in colorectal …
mitogenic metabolites of arachidonic acid such as prostaglandin E2 (PGE2) in colorectal …
Urinary Prostaglandin E2 Metabolite and Gastric Cancer Risk in the Shanghai Women's Health Study
Chronic inflammation has been implicated in the etiology of gastric cancer. Prostaglandin E2
(PGE2) is one of the major end-products of the cyclooxygenase-2 pathway, an enzyme that …
(PGE2) is one of the major end-products of the cyclooxygenase-2 pathway, an enzyme that …
Urinary PGE-M levels are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs
Abstract Prostaglandin E2 (PGE2) promotes colorectal carcinogenesis. Overall, systemic
PGE2 production can be assessed by measuring its major metabolite, PGE-M, in urine. We …
PGE2 production can be assessed by measuring its major metabolite, PGE-M, in urine. We …
A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk
Background. Previous studies suggest that a stable end-product of prostaglandin E2, the
urinary metabolite PGE-M, is associated with colorectal cancer, and 1 study of relatively …
urinary metabolite PGE-M, is associated with colorectal cancer, and 1 study of relatively …
Levels of Prostaglandin E Metabolite, the Major Urinary Metabolite of Prostaglandin E2, Are Increased in Smokers
ND Gross, JO Boyle, JD Morrow, MK Williams… - Clinical cancer …, 2005 - AACR
Purpose: Increased levels of cyclooxygenase-2 and prostaglandin E2 (PGE2) have been
observed in tobacco-related malignancies of the upper aerodigestive tract. Moreover …
observed in tobacco-related malignancies of the upper aerodigestive tract. Moreover …
COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention
C Pereira, P Pimentel-Nunes, C Brandão… - European journal of …, 2010 - journals.lww.com
Objective COX-2, the inducible isoenzyme, was found to be overexpressed in approximately
85% of colorectal adenocarcinomas, contributing to key steps in tumor development. COX-2 …
85% of colorectal adenocarcinomas, contributing to key steps in tumor development. COX-2 …
Urinary Prostaglandin E2 Metabolite and Breast Cancer Risk
Background: Levels of the cyclooxygenase 2 (COX2) enzyme are elevated in breast cancer
tissue, and most COX2 effects are believed to be mediated through overproduction of …
tissue, and most COX2 effects are believed to be mediated through overproduction of …