Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease, with typical motor symptoms as the main clinical manifestations. At …

Abstract Aims The etiology of Parkinson's disease (PD) is complex and the mechanism is
unclear. It has become a top priority to find common factors that induce and affect PD …

Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol
SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and …

Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

A link between chronic stress and Parkinson's disease (PD) pathogenesis is emerging.
Ample evidence demonstrates that the presynaptic neuronal protein alpha-synuclein (asyn) …

Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the
hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy …

Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …

The identification of three genes and several additional loci associated with inherited forms
of levodopa-responsive PD has confirmed that this is not a single disorder. Yet, analyses of …

Background: Parkinson's disease (PD) is a multifactorial, chronic, and progressive
neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of …

α-Synuclein (SYN) is the major component of Lewy bodies, the neuropathological hallmarks
of Parkinson's disease (PD). Missense mutations and multiplications of the SYN gene cause …