New designs for phototherapeutic transition metal complexes

C Imberti, P Zhang, H Huang… - Angewandte Chemie …, 2020 - Wiley Online Library
In this Minireview, we highlight recent advances in the design of transition metal complexes
for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the …

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

L Gourdon, K Cariou, G Gasser - Chemical Society Reviews, 2022 - pubs.rsc.org
Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) are therapeutic
techniques based on a photosensitizer (PS) and light. These techniques allow the spatial …

Designing red‐light‐activated multifunctional agents for the photodynamic therapy

SLH Higgins, KJ Brewer - Angewandte Chemie International Edition, 2012 - infona.pl
Cell death by visible light: Photodynamic therapy (PDT) is a relatively underemployed
method for treatment of diseases including cancer. Recent improvements in synthetic and …

Beyond photodynamic therapy: light-activated cancer chemotherapy

W Szymanski - Current Medicinal Chemistry, 2017 - ingentaconnect.com
Background: Cancer chemotherapy is limited by severe side effects due to unspecific
cytotoxic activity of currently used therapeutics. In order to minimize these unwanted effects …

Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine

NJ Farrer, L Salassa, PJ Sadler - Dalton Transactions, 2009 - pubs.rsc.org
The fields of phototherapy and of inorganic chemotherapy both have long histories.
Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over …

Transition metal complexes as photosensitisers in one-and two-photon photodynamic therapy

LK McKenzie, HE Bryant, JA Weinstein - Coordination Chemistry Reviews, 2019 - Elsevier
Photodynamic therapy (PDT) exploits light-activated compounds for therapeutic use. It relies
on a photosensitiser (PS) that is inactive in the absence of light. When irradiated, the PS …

New avenues in the design and potential application of metal complexes for photodynamic therapy

OJ Stacey, SJA Pope - Rsc Advances, 2013 - pubs.rsc.org
Photodynamic therapy (PDT) requires a photosensitizing agent, which can undergo visible
light activation, yielding reactive oxygen species and/or radical species. The key physical …

Photoswitching the cytotoxic properties of platinum (II) compounds

A Presa, RF Brissos, AB Caballero… - Angewandte Chemie …, 2015 - Wiley Online Library
The photoactivation of potential anticancer metal complexes is a hot topic of current
research as it may lead to the development of more selective drugs. Photoactivated …

Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?

SA McFarland, A Mandel, R Dumoulin-White… - Current opinion in …, 2020 - Elsevier
Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of
cancer. It has been used to complement traditional anticancer modalities such as surgery …

Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy

J Karges, H Chao, G Gasser - JBIC Journal of Biological Inorganic …, 2020 - Springer
Photodynamic therapy is a light-activated medical technique, which has received increasing
attention within the last decade to treat various diseases including bacterial, viral or fungal …