COVID-19-associated ARDS treated with DEXamethasone (CoDEX): study design and rationale for a randomized trial

BM Tomazini, IS Maia, FR Bueno… - Revista Brasileira de …, 2020 - SciELO Brasil
Objective: The infection caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) spreads worldwide and is considered a pandemic. The most common …

Efficacy of dexamethasone treatment for patients with the acute respiratory distress syndrome caused by COVID-19: study protocol for a randomized controlled …

J Villar, JM Añón, C Ferrando, G Aguilar, T Muñoz… - Trials, 2020 - Springer
Background There are no specific generally accepted therapies for the coronavirus disease
2019 (COVID-19). The full spectrum of COVID-19 ranges from asymptomatic disease to mild …

High dose dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to COVID-19: a structured summary of a study protocol for a randomised …

LP Maskin, GL Olarte, F Palizas, AE Velo, MF Lurbet… - Trials, 2020 - Springer
Objectives The aim of this study is to explore the effectiveness and safety of high dose
dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to SARS-Cov …

No clinical benefit of high dose corticosteroid administration in patients with COVID-19: a preliminary report of a randomized clinical trial

H Jamaati, SMR Hashemian, B Farzanegan… - European journal of …, 2021 - Elsevier
The aim of this study was to evaluate the clinical effects of dexamethasone administration in
patients with mild to moderate acute respiratory distress syndrome (ARDS) due to …

High-versus low-dose dexamethasone for the treatment of COVID-19-related acute respiratory distress syndrome: a multicenter, randomized open-label clinical trial

LP Maskin, I Bonelli, GL Olarte… - Journal of intensive …, 2022 - journals.sagepub.com
Objective To determine whether high-dose dexamethasone increases the number of
ventilator-free days (VFD) among patients with acute respiratory distress syndrome (ARDS) …

High-dose dexamethasone treatment for COVID-19 severe acute respiratory distress syndrome: a retrospective study

A Vecchié, A Batticciotto, F Tangianu… - Internal and Emergency …, 2021 - Springer
Low-dose dexamethasone reduces mortality in patients with coronavirus disease 2019
(COVID-19)-related acute respiratory distress syndrome (ARDS). We retrospectively …

Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: the CoDEX …

BM Tomazini, IS Maia, AB Cavalcanti, O Berwanger… - Jama, 2020 - jamanetwork.com
Importance Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019
(COVID-19) is associated with substantial mortality and use of health care resources …

Dexamethasone for treating SARS-CoV-2 infection: a systematic review and meta-analysis

LED Ferreto, DS Bortoloti, PCN Fortes… - Sao Paulo Medical …, 2021 - SciELO Brasil
ABSTRACT BACKGROUND: Considering the disruptions imposed by lockdowns and social
distancing recommendations, coupled with overwhelmed healthcare systems, researchers …

High-dose steroids for nonresolving acute respiratory distress syndrome in critically ill COVID-19 patients treated with dexamethasone: a multicenter cohort study

J Lopinto, R Arrestier, B Peiffer, A Gaillet… - Critical Care …, 2023 - journals.lww.com
OBJECTIVES: To determine the impact of high doses of corticosteroids (HDCT) in critically ill
COVID-19 patients with nonresolving acute respiratory distress syndrome (ARDS) who had …

Comparison of the efficacy of equivalent doses of dexamethasone, methylprednisolone, and hydrocortisone for treatment of COVID-19-related acute respiratory …

A Taher, M Lashkari, F Keramat, SH Hashemi… - Wiener Medizinische …, 2023 - Springer
Background This prospective controlled clinical trial aimed to compare the efficacy of
methylprednisolone, dexamethasone, and hydrocortisone at equivalent doses in patients …