Short-term and repeated exposure to particulate matter sizes from Imperial Valley, California to induce inflammation and asthmatic-like symptoms in mice

SM D'Evelyn, KJ Bein, EA Laing, T Nyguen… - Journal of Toxicology …, 2023 - Taylor & Francis
ABSTRACT Imperial Valley, California has become increasingly hot, dry, and polluted over
the past decade. Particulate matter (PM) levels are amongst the highest in this State …

Lung response to coarse PM: bioassay in mice

TC Wegesser, JA Last - Toxicology and applied pharmacology, 2008 - Elsevier
Particulate matter (PM) elicits inflammatory and toxic responses in the lung specific to its
constituents, which can vary by region, time, and particle size. To identify the mechanism of …

Airborne particles of the california central valley alter the lungs of healthy adult rats.

KR Smith, S Kim, JJ Recendez… - Environmental …, 2003 - ehp.niehs.nih.gov
Epidemiologic studies have shown that airborne particulate matter (PM) with a mass median
aerodynamic diameter< 10 microm (PM10) is associated with an increase in respiratory …

Characterization of urban atmospheres during inhalation exposure studies in Detroit and Grand Rapids, Michigan

GJ Keeler, M Morishita, JG Wagner… - Toxicologic …, 2007 - journals.sagepub.com
An inhalation exposure study for particulate matter (PM) investigates links between
exposure and observed changes in respiratory function by evaluating the interactions of …

Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit

M Morishita, GJ Keeler, JG Wagner, FJ Marsik… - Inhalation …, 2004 - Taylor & Francis
A collaborative research study was conducted in order to improve our understanding of the
source-to-receptor pathway for ambient fine particulate matter (aerodynamic diameter≤ 2.5 …

Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies

JG Wagner, M Morishita, GJ Keeler, JR Harkema - Environmental Health, 2012 - Springer
Background Increases in ambient particulate matter of aerodynamic diameter of 2.5 μm (PM
2.5) are associated with asthma morbidity and mortality. The overall objective of this study …

Mouse lung inflammation after instillation of particulate matter collected from a working dairy barn

TC Wegesser, JA Last - Toxicology and applied pharmacology, 2009 - Elsevier
Coarse and fine particulate matter (PM2. 5–10 and PM2. 5, respectively) are regulated
ambient air pollutants thought to have major adverse health effects in exposed humans. The …

Pulmonary inflammatory effects of source-oriented particulate matter from California's San Joaquin Valley

LE Plummer, CM Carosino, KJ Bein, Y Zhao… - Atmospheric …, 2015 - Elsevier
The EPA regulates ambient particulate matter (PM) because substantial associations have
been established between PM and health impacts. Presently, regulatory compliance …

Inhalation of concentrated particulate matter produces pulmonary inflammation and systemic biological effects in compromised rats

FR Cassee, AJF Boere, PHB Fokkens… - Journal of Toxicology …, 2005 - Taylor & Francis
Although significant progress has been made over the past few years, there is still debate on
the causal fractions that are responsible for particulate matter (PM)-associated adverse …

Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in mice

DM Walters, PN Breysse… - American journal of …, 2001 - atsjournals.org
Airborne particulate matter (PM) is hypothesized to play a role in increases in asthma
prevalence, although a causal relationship has yet to be established. To investigate the …