▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …

The four mammalian neurotrophins—NGF, BDNF, NT-3 and NT-4—each bind and activate
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …

trkC receptors, which serve critical functions during the development of the nervous system,
are alternatively spliced to yield isoforms containing the catalytic tyrosine kinase domain …

The initial event in the neuronal differentiation of PC12 cells is the binding of the
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …

A family of tyrosine receptor kinases known collectively as trk receptors plays an essential
role in signal transduction mediated by nerve growth factor and related neurotrophins. To …

Neurotrophins, such as NGF and BDNF, activate Trk receptor tyrosine kinases through
receptor dimerization at the cell surface followed by autophosphorylation and intracellular …

Imbalances in neurotrophins or their high-affinity Trk receptors have long been reported in
neurodegenerative diseases. However, a molecular link between these gene products and …

Ligands for G protein-coupled receptors (GPCR) are capable of activating mitogenic
receptor tyrosine kinases, in addition to the mitogen-activated protein (MAP) kinase …

Neurotrophins signal via Trk tyrosine kinase receptors and a common receptor called p75.
Nerve growth factor is the cognate ligand for TrkA, brain-derived neurotrophic factor for TrkB …

TrkB belongs to the Trk family of tyrosine kinase receptors and mediates the response to
brain‐derived neurotrophic factor (BDNF) and neurotrophin‐4/5 (NT‐4/5). Here, we report …