Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs)
with unclear pathogenesis and uncertain treatment. In experimental colitis mouse models …

As the global population ages, bone‐related diseases have increasingly become a major
social problem threatening human health. Exosomes, as natural cell products, have been …

The effective healing of a bone defect is dependent on the careful coordination of
inflammatory and bone-forming cells. In the current work, pro-inflammatory M1 and anti …

The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal
stem cells (BMSCs) characterizes many pathological bone loss conditions. Stromal cell …

Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play
an important role in cellular communication during skeletal growth and homeostasis …

Stem cell-derived exosomes have exhibited promise for applications in tissue regeneration.
However, one major problem for stem cell-derived exosome therapies is identifying …

In elderly people particularly in postmenopausal women, inadequate bone formation by
osteoblasts originating from bone marrow mesenchymal stem cells (BMSCs) for …

Background. In the past decade, mesenchymal stem cells (MSCs) have been widely used
for the treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major …

Inflammatory bowel disease (IBD) remains a severe disease for most patients, with its
incidence and prevalence increasingly globally. Currently, there is no effective treatments for …

Background Skeletal unloading usually induces severe disuse osteoporosis (DOP), which
often occurs in patients subjected to prolonged immobility or in spaceflight astronauts …