The year 2007 brought with it several reminders of the importance of drug-induced liver
injury in the clinical trial as well as the clinical practice setting. There is additional evidence …

The “statins,” or hydroxymethylglutaryl coenzyme A (HMG-CoA)-reductase inhibitors, are a
generally safe class of drugs that are widely used throughout the world and are rarely …

Statins are inhibitors of hydroxymethylglutaryl coenzyme A reductase, the enzyme that
catalyzes the rate-limiting step of the cholesterol biosynthetic pathway. As a class, statins are …

The HMG‐CoA reductase inhibitors (statins) are widely prescribed for patients with
hyperlipidemia and are generally well tolerated. Mild elevations in serum aminotransferases …

Since their introduction in 1987, hydroxymethyl glutaryl coenzyme A reductase (HMG-CoA)
inhibitors, more commonly known as statins, have become some of the most widely …

Statins are among the most widely prescribed medi-cations in the western world. 1 Their
benefit in the primary and secondary prevention of cardiovascular disease is unequivocal …

Statins are given to 10–20% of adults in developed countries. Statins increase alanine
aminotransferase (ALT) concentrations in 10% of patients without liver disease, and this …

Abstract Background and Aim The hepatotoxicity of statins in patients with chronic liver
diseases remains unclear. In this study, we aimed to estimate the risk of severe hepatic …

The hydroxymethyglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (also known as
statins) are a very commonly prescribed class of medications for the treatment of …

Statins are generally well tolerated and adverse effects are relatively rare. Clinical trials are
underpowered to detect uncommon adverse effects such as idiosyncratic drug‐induced liver …