While immunoglobulin A (IgA) is well known for its neutralizing and anti-inflammatory
function, it is becoming increasingly clear that IgA can also induce human inflammatory …

Human IgA could be from different isotypes (IgA1/IgA2) and/or isoforms (monomeric,
dimeric, or secretory). Monomeric IgA mainly IgA1 are considered as an anti‐inflammatory …

IgA is predominantly recognized to play an important role in host defense at mucosal sites,
where it prevents invasion of pathogens by neutralization. Although it has recently become …

The intestinal mucosa is a physiological barrier for most microbes, including both
commensal bacteria and invading pathogens. Under homeostatic conditions …

The intestinal mucosal immune environment requires multiple immune cells to maintain
homeostasis. Although intestinal B cells are among the most important immune cells, little is …

Intestinal DCs orchestrate gut immune homeostasis by dampening proinflammatory T‐cell
responses and inducing anti‐inflammatory IgA responses. Although no specific DC subset …

Abstract CD103+ dendritic cells (DC) are crucial for regulation of intestinal tolerance in
humans. However, upon infection of the lamina propria this tolerogenic response is …

Background The G protein alpha subunit type-2 (Gαi2)-deficient mouse develops
inflammatory bowel disease (IBD) with increased severity in mice on a 129SvEv (129) …

Patients with inflammatory bowel disease (IBD) produce enhanced immunoglobulin A (IgA)
against the microbiota compared to healthy individuals, which has been correlated with …

Dysregulated B cell responses have been described in inflammatory bowel disease (IBD)
patients; however, the role of B cells in IBD pathology remained incompletely understood …