Background Chemokine-mediated neuroinflammation plays an important role in the
pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor …

Purpose Trigeminal neuropathic pain is very common clinically, but effective treatments are
lacking. Chemokines and their receptors have been implicated in the pathogenesis of …

Background Neuropathic pain in the trigeminal system is frequently observed in clinic, but
the mechanisms involved are largely unknown. In addition, the function of immune cells and …

Background Trigeminal nerve damage-induced neuropathic pain is a severely debilitating
chronic orofacial pain syndrome. Spinal chemokine CXCL13 and its receptor CXCR5 were …

Background Chemokine axis chemokine CXC motif ligand 12/CXC chemokine receptor type
4 (CXCL12/CXCR4) is an emerging pain modulator, but mechanisms for its involvement in …

Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and
contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro …

This study investigated the functional significance of hyperalgesia in the CCL2/CCR2
signaling system in trigeminal ganglion (TG) neurons following inflammation. Inflammation …

Recent studies suggest that peripheral nerve injury converts resting spinal cord astroglial
cells into an activated state, which is required for the development and maintenance of …

Background: The chemokine family has been revealed to be involved in the pathogenesis of
neuropathic pain. In this study, the authors investigated the role of chemokine (CC motif) …

Recent studies have implicated chemokines in microglial activation and pathogenesis of
neuropathic pain. CXC motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant …