The RING domain protein RNF11 is overexpressed in breast cancers and promotes tumour
growth factor‐beta (TGF‐β) signalling. RNF11 has been proposed to regulate TGF‐β …

The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and
cytokine-mediated activation of the transcription factor NF-κB; however, little is known about …

The NF‐κB transcription factor is normally transiently activated by proinflammatory cytokines
and bacterial lipopolysaccharide (LPS); however, persistent NF‐κB activation is commonly …

In response to stimulation with proinflammatory cytokines, the deubiquitinase A20 inducibly
interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin …

A20 has been suggested to limit NF‐κB activation by removing regulatory ubiquitin chains
from ubiquitinated substrates. A20 is a ubiquitin‐editing enzyme that removes K 63‐linked …

Nuclear factor κB (NF-κB) activation in tumor necrosis factor, interleukin-1, and Toll-like
receptor pathways requires Lys63-linked nondegradative polyubiquitination. A20 is a …

Nuclear factor (NF)-κB has an important role in immunity and inappropriate NF-κB activity
has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms …

Ubiquitination and deubiquitination of receptor-interacting protein 1 (RIP1) play an important
role in the positive and negative regulation of the tumor necrosis factor α (TNFα)-induced …

Deregulation of the transcription factor NF-κB can mediate several inflammatory diseases in
addition to cancer. Therefore, several proteins, including the zinc finger protein A20, tightly …

Ubiquitin ligases are critical components of the ubiquitination process that determine
substrate specificity and, in collaboration with E2 ubiquitin‐conjugating enzymes, regulate …