Macrophages are present in all mammalian tissues and coexist with various cell types in
order to respond to different environmental cues. However, the role of these cells has been …

The mature peripheral nervous system is a steady network structure yet shows remarkable
regenerative properties. The interaction of peripheral nerves with myeloid cells has largely …

Macrophage-mediated segmental demyelination is the pathological hallmark of autoimmune
demyelinating polyneuropathies, including the demyelinating form of Guillain-Barré …

The peripheral nervous system (PNS) has remarkable regenerative abilities after injury.
Successful PNS regeneration relies on both injured axons and non-neuronal cells, including …

Macrophages of the peripheral nervous system belong to the so-called tissue macrophages,
with multiple functions during injury and disease. Their origin during ontogeny has not yet …

This review article on the degeneration and regeneration of peripheral nerve fibers was
presented as a Plenary Lecture at the 2001 meeting of the Peripheral Nerve Society. It is …

In this article we first discuss the factors that regulate macrophage recruitment, activation,
and myelin phagocytosis during Wallerian degeneration and some of the factors involved in …

The role of innate and adaptive inflammation as a primary driver or modifier of neuropathy in
premorbidly normal nerves, and as a critical player in amplifying neuropathies of other …

In this review, we first provide a brief historical perspective, discussing how peripheral nerve
injury (PNI) may have caused World War I. We then consider the initiation, progression, and …

Peripheral neuropathies are associated with a variety of clinical symptoms ranging from
motor and sensory symptoms to autonomic dysfunction. The primary disease causes for …