Hypoxia can act as an initial trigger to induce erythrocyte sickling and eventual end organ
damage in sickle cell disease (SCD). Many factors and metabolites are altered in response …

Sickle cell disease (SCD) is a debilitating hemolytic genetic disorder with high morbidity and
mortality affecting millions of individuals worldwide. Although SCD was discovered more …

New insights into sickle cell disease: a disease of hypoxia : Current Opinion in Hematology
New insights into sickle cell disease: a disease of hypoxia : Current Opinion in Hematology Log …

The discovery of the molecular basis of sickle cell disease was an important landmark in
molecular medicine. The modern tools of molecular and cellular biology have refined our …

Sickle cell disease (SCD) is the most-common monogenic recessive disease in humans,
annually affecting almost 300,000 newborns worldwide, 75% of whom live in Africa …

Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …

Sickle cell disease is caused by an alteration in a single DNA base, but its clinical
manifestations are influenced by other genes and behavioral and environmental factors …

Sickle cell disease (SCD) is an autosomal-recessive hemolytic disorder with high morbidity
and mortality. The pathophysiology of SCD is characterized by the polymerization of …

Erythrocyte possesses high sphingosine kinase 1 (SphK1) activity and is the major cell type
supplying plasma sphingosine-1-phosphate, a signaling lipid regulating multiple …

Small molecules that increase the oxygen affinity of human hemoglobin may reduce sickling
of red blood cells in patients with sickle cell disease. We screened 38 700 compounds using …