Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s
P Roy, J Maturano, H Hasdemir, A Lopez… - Journal of Natural …, 2024 - ACS Publications
Cannabichromene (CBC) is a nonpsychoactive phytocannabinoid well-known for its wide-
ranging health advantages. However, there is limited knowledge regarding its human …
ranging health advantages. However, there is limited knowledge regarding its human …
[HTML][HTML] Identification and Characterization of Cannabichromene's Major Metabolite Following Incubation with Human Liver Microsomes
AM Ward, T Shokati, J Klawitter, J Klawitter, V Nguyen… - Metabolites, 2024 - mdpi.com
Cannabichromene (CBC) is a minor cannabinoid within the array of over 120 cannabinoids
identified in the Cannabis sativa plant. While CBC does not comprise a significant portion of …
identified in the Cannabis sativa plant. While CBC does not comprise a significant portion of …
Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
S Yamaori, Y Kinugasa, R Jiang, S Takeda… - Life sciences, 2015 - Elsevier
Aims We herein investigated the inducibility of cytochrome P450 1A1 (CYP1A1) by Δ 9-
tetrahydrocannabinol, cannabidiol (CBD), and cannabinol, three major phytocannabinoids …
tetrahydrocannabinol, cannabidiol (CBD), and cannabinol, three major phytocannabinoids …
Metabolites of cannabigerol generated by human cytochrome P450s are bioactive
The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many
cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the …
cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the …
Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol
S Yamaori, Y Okushima, I Yamamoto… - Chemico-Biological …, 2014 - Elsevier
We previously demonstrated that cannabidiol (CBD) was a potent mechanism-based
inhibitor of human cytochrome P450 1A1 (CYP1A1). However, the moiety of CBD that …
inhibitor of human cytochrome P450 1A1 (CYP1A1). However, the moiety of CBD that …
[HTML][HTML] Comparative metabolomic profiling of the metabolic differences of Δ9-tetrahydrocannabinol and cannabidiol
Q Rao, T Zhang, M Dai, B Li, Q Pu, M Zhao, Y Cheng… - Molecules, 2022 - mdpi.com
More than one hundred cannabinoids have been found in cannabis. Δ9-
Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however …
Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however …
Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
R Jiang, S Yamaori, S Takeda, I Yamamoto… - Life sciences, 2011 - Elsevier
AIMS: Cannabidiol (CBD), one of the major constituents in marijuana, has been shown to be
extensively metabolized by experimental animals and humans. However, human hepatic …
extensively metabolized by experimental animals and humans. However, human hepatic …
Cytochrome P450–catalyzed metabolism of cannabidiol to the active metabolite 7-hydroxy-cannabidiol
JL Beers, D Fu, KD Jackson - Drug Metabolism and Disposition, 2021 - ASPET
Cannabidiol (CBD) is a naturally occurring nonpsychotoxic phytocannabinoid that has
gained increasing attention as a popular consumer product and for its use in Food and Drug …
gained increasing attention as a popular consumer product and for its use in Food and Drug …
Characterization of cannabidiol-mediated cytochrome P450 inactivation
LM Bornheim, ET Everhart, J Li, MA Correia - Biochemical pharmacology, 1993 - Elsevier
Cannibidiol (CBD) has been shown to impair hepatic drug metabolism in several animal
species and to markedly inhibit mouse hepatic microsomal Δ 1-tetrahydrocannabinol (THC) …
species and to markedly inhibit mouse hepatic microsomal Δ 1-tetrahydrocannabinol (THC) …
[HTML][HTML] Cannabidiol metabolism revisited: Tentative identification of novel decarbonylated metabolites of cannabidiol formed by human liver microsomes and …
K Watanabe, N Usami, S Osada, S Narimatsu… - Forensic …, 2019 - Springer
Purpose The purpose of the present study was to identify the structures of cannabidiol (CBD)
metabolites during CO formation by human liver microsomes and human recombinant …
metabolites during CO formation by human liver microsomes and human recombinant …