The chemically simple, biologically complex eukaryotic polyamines, spermidine and
spermine, are positively charged alkylamines involved in many crucial cellular processes …

The polyamines spermidine and spermine and their diamine precursor putrescine are
naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth …

Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

Polyamines, including spermine, spermidine, and the precursor diamine, putrescine, are
naturally occurring polycationic alkylamines that are required for eukaryotic cell growth …

Polyamines are ubiquitous positively charged amines found in all organisms. These
molecules play a crucial role in many biological functions including cell growth, gene …

Polyamines are small organic cations that are essential for normal cell growth and
development in eukaryotes. Under normal physiological conditions, intracellular polyamine …

Advances in our understanding of the metabolism and molecular functions of polyamines
and their alterations in cancer have led to resurgence in the interest of targeting polyamine …

The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are
ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating …

Spermidine, as a natural component from polyamine members, is originally isolated from
semen and also existed in many natural plants, and can be responsible for cell growth and …

Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are
intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are …