Protective effect of wedelolactone against CCl4-induced acute liver injury in mice

Y Lu, DM Hu, SB Ma, X Zhao, S Wang, G Wei… - International …, 2016 - Elsevier
Eclipta, a traditional Chinese medicine, has been used to treat liver disease for centuries.
However, the chemical basis and biological mechanisms of Eclipta remain elusive. The …

Hepatoprotective effect of wedelolactone against concanavalin A-induced liver injury in mice

Q Luo, J Ding, L Zhu, F Chen, L Xu - The American Journal of …, 2018 - World Scientific
Eclipta prostrata L. is a traditional Chinese herbal medicine that has been used in the
treatment of liver diseases. However, its biological mechanisms remain elusive. The current …

Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2

Y Xia, J Chen, Y Cao, C Xu, R Li, Y Pan… - European journal of …, 2013 - Elsevier
Wedelolactone is a major coumarin of Eclipta prostrata, which is used for preventing liver
damage. However the effects of wedelolactone on hepatic fibrosis remained unexplored …

Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-κB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and …

MQ Wang, KH Zhang, FL Liu, R Zhou, Y Zeng, AL Chen… - Phytomedicine, 2024 - Elsevier
Background Cholestatic liver diseases (CLD) comprise a variety of disorders of bile
formation, which causes chronic exposure to bile acid (BA) in the liver generally and results …

The protective effect of Esculentoside A on experimental acute liver injury in mice

F Zhang, X Wang, X Qiu, J Wang, H Fang, Z Wang… - PloS one, 2014 - journals.plos.org
Inflammatory response and oxidative stress are considered to play an important role in the
development of acute liver injury induced by carbon tetrachloride (CCl4) and galactosamine …

Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving …

M Wang, J Niu, L Ou, B Deng, Y Wang, S Li - Molecules, 2019 - mdpi.com
The natural compound Zerumbone (hereinafter referred to as ZER), a monocyclic
sesquiterpenoid, has been reported to possess many pharmacological properties, including …

Network pharmacology and in vivo studies reveal the pharmacological effects and molecular mechanisms of Celastrol against acute hepatic injury induced by LPS

T Yang, S Zhao, N Sun, Y Zhao, H Wang… - International …, 2023 - Elsevier
Sepsis is currently the main factor of death in the ICU, and the liver, as an important organ of
immunity and stable metabolism, can be acutely damaged during sepsis, and the mortality …

Fucosterol Protects against Concanavalin A‐Induced Acute Liver Injury: Focus on P38 MAPK/NF‐κB Pathway Activity

W Mo, C Wang, J Li, K Chen, Y Xia, S Li… - Gastroenterology …, 2018 - Wiley Online Library
Objective. Fucosterol is derived from the brown alga Eisenia bicyclis and has various
biological activities, including antioxidant, anticancer, and antidiabetic properties. The aim of …

Oleoylethanolamide protects against acute liver injury by regulating Nrf-2/HO-1 and NLRP3 pathways in mice

J Hu, Z Zhu, H Ying, J Yao, H Ma, L Li… - Frontiers in …, 2021 - frontiersin.org
Acute liver injury is a rapidly deteriorating clinical condition with markedly high morbidity and
mortality. Oleoylethanolamide (OEA) is an endogenous lipid messenger with multiple …

Echinacoside from Cistanche tubulosa ameliorates alcohol‐induced liver injury and oxidative stress by targeting Nrf2

Y Ding, Y Zhang, Z Wang, F Zeng, Q Zhen… - The FASEB …, 2023 - Wiley Online Library
Abstract Cistanche tubulosa (Schrenk) Wight, named Guan hua Rou Cong‐Rong in
Chinese, is a traditional plant with liver, kidney, and intestine protective effects …