G9a, a histone methyltransferase, has been found to be upregulated in a range of tumor
tissues, and contributes to tumor growth and metastasis. However, the impact of G9a …

Histone methylation plays an important role in gene transcription and chromatin
organization and is linked to the silencing of a number of critical tumor suppressor genes in …

A histone methyltransferase G9a, encoded by euchromatic histone-lysine N-
methyltransferase 2 (EHMT2), is up-regulated in various cancers, and is involved in their …

Background: Histone methyltransferase G9a is up-regulated in a wide variety of human
tumors. The aims of this study are to clarify G9a expression in tumor tissues and its adjacent …

Background Head and neck squamous cell carcinoma (HNSCC) is a common cancer
worldwide. Emerging evidence indicates that alteration of epigenetics might be a key event …

Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis
despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone …

Objective To explore whether inhibition of H3K9 Methyltransferase G9a could exert an
antitumoral effect in oral squamous cell carcinoma (OSCC). Materials and methods First we …

As an important methyltransferase, G9a has been reported to be abnormally expressed in
various human cancers and plays essential roles in tumorigenesis. However, the biologic …

G9a, a histone methyltransferase, is aberrantly expressed in some human tumor types. By
comparing 182 paired colorectal cancer and peritumoral tissues, we found that G9a was …

Objective: The aim of this study is to investigate the effect of G9a inhibitor BIX-01294 on
attenuating cell proliferation in human lung adenocarcinoma A549 cell line and the …