Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the
degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA …

Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces
persistent pain and disabilities. The development of OA is a complex process, and the risk …

Elevated levels of pro-inflammatory cytokines are generally thought to be responsible for
driving the progression of synovial joint inflammation in rheumatoid arthritis (RA) and …

The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signaling
pathway serves as an important downstream mediator for a variety of cytokines, hormones …

Proinflammatory cytokine activation of the Janus kinase/signal transducers and activators of
transcription (JAK/STAT) signal transduction pathway is a critical event in the pathogenesis …

JAK/STAT signaling pathway is involved in many diseases, including autoimmune diseases,
which are characterized by a close interconnection between immune and bone system …

Rheumatoid arthritis (RA) is classified as an inflammatory, chronic autoimmune and
disabling disease based on the intricate interplay between environmental and genetic …

Osteoarthritis (OA), the most prevalent form of arthritis disease, is characterized by
destruction of articular cartilage, osteophyte development, and sclerosis of subchondral …

Spondyloarthritis (SpA) comprises a group of chronic inflammatory diseases with
overlapping clinical, genetic and pathophysiological features including back pain, peripheral …

Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue.
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …