Purpose: Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its
role in causing resistance to radiotherapy. Hypoxia arises in tumor regions distal to blood …

Over the last decade, evidence has emerged to support a role for the antidiabetic drug
metformin in the prevention and treatment of cancer. In particular, recent studies …

Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or
in combination with ionizing radiation were studied with MCF-7 human breast cancer cells …

An important mechanism of action of metformin as an antidiabetic drug involves inhibition of
hepatic gluconeogenesis, but the molecular basis for this is controversial. A recent …

Background: We examined the potential of metformin (MET) to enhance non-small cell lung
cancer (NSCLC) responses to ionising radiation (IR). Methods: Human NSCLC cells, mouse …

Late-phase clinical trials investigating metformin as a cancer therapy are underway.
However, there remains controversy as to the mode of action of metformin in tumors at …

Metformin is one of the most commonly prescribed medications for the treatment of type 2
diabetes. Numerous reports have suggested potential anti-cancerous and cancer preventive …

Repurposing metformin for cancer therapy is attractive due to its safety profile,
epidemiological evidence, and encouraging data from human clinical trials. Although it is …

Background Metformin is widely used in the treatment of diabetes, and there is interest in
'repurposing'the drug for cancer prevention or treatment. However, the mechanism …