Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

M Mauthe, I Orhon, C Rocchi, X Zhou, M Luhr… - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …

[HTML][HTML] Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress

MA Rahman, ASM Saikat, MS Rahman, M Islam… - Cells, 2023 - mdpi.com
Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Chloroquine and hydroxychloroquine for cancer therapy

G Manic, F Obrist, G Kroemer, I Vitale… - Molecular & cellular …, 2014 - Taylor & Francis
Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the
lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance …

Autophagy modulation: a target for cancer treatment development

A Duffy, J Le, E Sausville, A Emadi - Cancer chemotherapy and …, 2015 - Springer
Purpose Regulation of cellular death is a complex method to maintain cellular homeostasis
by protecting against oncogenic development and by recycling damaged cellular debris …

[HTML][HTML] Therapeutic targeting of autophagy

CG Towers, A Thorburn - EBioMedicine, 2016 - thelancet.com
Autophagy is a catabolic process that facilitates nutrient recycling via degradation of
damaged organelles and proteins through lysosomal mediated degradation. Alterations in …

Targeting autophagy in cancer

AV Onorati, M Dyczynski, R Ojha, RK Amaravadi - Cancer, 2018 - Wiley Online Library
Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular
homeostasis during stress conditions. Dysregulated autophagy has implications in health …

Recent advances in targeting autophagy in cancer

V Jain, MP Singh, RK Amaravadi - Trends in Pharmacological Sciences, 2023 - cell.com
Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …

[HTML][HTML] Combination of an autophagy inducer and an autophagy inhibitor: a smarter strategy emerging in cancer therapy

T Liu, J Zhang, K Li, L Deng, H Wang - Frontiers in pharmacology, 2020 - frontiersin.org
Autophagy is considered a cytoprotective function in cancer therapy under certain conditions
and is a drug resistance mechanism that represents a clinical obstacle to successful cancer …

Autophagy inhibitors for cancer therapy: small molecules and nanomedicines

JL Chen, X Wu, D Yin, XH Jia, X Chen, ZY Gu… - Pharmacology & …, 2023 - Elsevier
Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …

Principles and current strategies for targeting autophagy for cancer treatment

RK Amaravadi, J Lippincott-Schwartz, XM Yin… - Clinical cancer …, 2011 - AACR
Autophagy is an evolutionarily conserved, intracellular self-defense mechanism in which
organelles and proteins are sequestered into autophagic vesicles that are subsequently …