Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice

KN Borrelli, EJ Yao, WW Yen, RA Phadke, QT Ruan… - ENeuro, 2021 - eneuro.org
The opioid epidemic led to an increase in the number of neonatal opioid withdrawal
syndrome (NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of …

[HTML][HTML] Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice

AD Dunn, SA Robinson, C Nwokafor, M Estill… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction: Infants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid
Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including …

[PDF][PDF] Opioid withdrawal behavior in spiny mice: A novel preclinical model of neonatal opioid withdrawal syndrome (NOWS)

S Stevens, S Mohan - Heliyon, 2021 - cell.com
As the opioid epidemic continues to grow, opioid use among pregnant women is increasing
significantly. This has led to a steady rise in the number of infants born with neonatal opioid …

Developmental opioid exposures: neurobiological underpinnings, behavioral impacts, and policy implications

SS Goldfarb, GD Stanwood, HA Flynn… - Experimental …, 2020 - journals.sagepub.com
The devastating impact of opioid abuse and dependence on the individual, family, and
society are well known but extremely difficult to combat. During pregnancy, opioid drugs and …

Maternal opioid exposure culminates in perturbed murine neurodevelopment and hyperactive phenotype in adolescence

CR Schlagal, TJ Dunn, P Xu, DE Felsing, CR Merritt… - Neuroscience, 2021 - Elsevier
Opioid use by women during pregnancy has risen dramatically since 2004, accompanied by
a striking increase in the prevalence of neonatal opioid withdrawal syndrome (NOWS) and …

Perinatal oxycodone exposure causes long-term sex-dependent changes in weight trajectory and sensory processing in adult mice

E Minakova, MO Mikati, MK Madasu, SM Conway… - …, 2022 - Springer
Rationale In utero opioid exposure is associated with lower weight and a neonatal opioid
withdrawal syndrome (NOWS) at birth, along with longer-term adverse neurodevelopmental …

[HTML][HTML] Ontogenetic oxycodone exposure affects early life communicative behaviors, sensorimotor reflexes, and weight trajectory in mice

E Minakova, S Sarafinovska, MO Mikati… - Frontiers in Behavioral …, 2021 - frontiersin.org
Nationwide, opioid misuse among pregnant women has risen four-fold from 1999 to 2014,
with commensurate increase in neonates hospitalized for neonatal abstinence syndrome …

[HTML][HTML] Advances in animal models of prenatal opioid exposure

JR Ferrante, JA Blendy - Trends in Neurosciences, 2024 - cell.com
Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The
complexity of in utero opioid exposure in clinical studies makes it difficult to investigate …

Neurobehavioral effects of neonatal opioid exposure in mice: influence of the OPRM1 SNP

SA Robinson, AD Jones, JK Brynildsen… - Addiction …, 2020 - Wiley Online Library
Opioid use among pregnant women is a growing public health concern in the United States.
Infants exposed to opioids in utero are at risk of exhibiting neonatal opioid withdrawal …

Maternal oxycodone treatment results in neurobehavioral disruptions in mice offspring

RE Martin, MT Green, JA Kinkade, RR Schmidt… - Eneuro, 2021 - eneuro.org
Opioid drugs are increasingly being prescribed to pregnant women. Such compounds can
also bind and activate opioid receptors in the fetal brain, which could lead to long-term brain …