Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor
post-surgical course after curative surgery. However, biomarkers stratifying this high-risk …

Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and
can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the …

Background Treatment strategies targeting tumor-associated macrophages (TAMs) have
been proposed in cancer areas. The functional alterations of macrophages in the …

Thrombospondin 1 and thrombospondin 2 (THBS1 and THBS2) share similar multifunctional
domains, and are known to be antiangiogenic. However, the expression pattern of THBS1 …

Background Lung cancer is a very heterogeneous disease that can be pathologically
classified into different subtypes including small-cell lung carcinoma (SCLC), lung …

Background Regulatory T cells (Tregs), are a key class of cell types in the immune system. In
the tumor microenvironment (TME), the presence of Tregs has important implications for …

Mesenchymal activation, characterized by dense stromal infiltration of immune and
mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving …

An immunosuppressive microenvironment enriched with regulatory CD4+ T lymphocytes
(Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to …

Tumor-associated macrophages (TAMs) are key components of tumor microenvironment
(TME) during tumorigenesis and progression. However, the role of TAMs in lung …

Abstract Background Tumor-associated macrophages (TAMs) have a leading position in the
tumor microenvironment. Previously, we have demonstrated that M1-like TAMs activated by …