International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

LJ Wu, TB Sweet, DE Clapham - Pharmacological reviews, 2010 - ASPET
Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine

B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Transient receptor potential (TRP) channels: a clinical perspective

Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels

DE Clapham, D Julius, C Montell, G Schultz - Pharmacological reviews, 2005 - ASPET
The transient receptor potential (TRP1) ion channels are named after the role of the
channels in Drosophila phototransduction. The mammalian genes are encoded by at least …

[HTML][HTML] Molecular mechanism of TRP channels

J Zheng - Comprehensive Physiology, 2013 - ncbi.nlm.nih.gov
Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

TRP ion channels in the nervous system

MM Moran, H Xu, DE Clapham - Current opinion in neurobiology, 2004 - Elsevier
The transient receptor potential (TRP) superfamily comprises a group of non-selective cation
channels that sense and respond to changes in their local environments. TRP channels are …

International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels

DE Clapham, C Montell, G Schultz, D Julius - Pharmacological reviews, 2003 - ASPET
The transient receptor potential (TRP) proteins are six transmembrane-containing subunits
that combine to form cation-selective ion channels. TRP channels are present in yeast …

Transient receptor potential channels as therapeutic targets

MM Moran, MA McAlexander, T Bíró… - Nature reviews Drug …, 2011 - nature.com
Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …