For multipinhole single-photon emission computed tomography (SPECT), iterative
reconstruction algorithms are preferred over analytical methods, because of the often …

Purpose Low sensitivity can become a major problem when very small pinholes are used in
SPECT imaging. Although a larger pinhole aperture will improve the sensitivity, this will be at …

Purpose: To assess the performance of two approaches to the system response matrix
(SRM) calculation in pinhole single photon emission computed tomography (SPECT) …

In conventional reconstruction of single photon emission computed tomography (SPECT)
data acquired with a single-pinhole or multipinhole system, the point spread function (PSF) …

Multipinhole single photon emission computed tomography (SPECT) imaging has several
advantages over single pinhole SPECT imaging, including an increased sensitivity and an …

Purpose In pinhole SPECT, attenuation of the photon flux on trajectories between source
and pinholes affects quantitative accuracy of reconstructed images. Previously we …

State-of-the-art multi-pinhole SPECT devices allow for sub-mm resolution imaging of radio-
molecule distributions in small laboratory animals. The optimization of multi-pinhole and …

Multi-pinhole collimators are often used in pre-clinical SPECT systems because they have a
better resolution-sensitivity tradeoff than parallel hole collimators when imaging small …

Previously, we developed a method to determine the acquisition geometry of a pinhole
camera. This information is needed for the correct reconstruction of pinhole single photon …

Single photon emission computed tomography (SPECT) is an important technology for
molecular imaging studies of small animals. In this arena, there is an increasing demand for …