Blood clots, which are composed of blood cells and a stabilizing mesh of fibrin fibers, are
critical in cessation of bleeding following injury. However, their action is transient and after …

Clotting and fibrinolysis are initiated simultaneously in vivo, and fibrinolysis usually occurs
without any individualized lysis front (intrinsic fibrinolysis). We have developed a novel …

Thrombosis, resulting in occlusive blood clots, blocks blood flow to downstream organs and
causes life-threatening conditions such as heart attacks and strokes. The administration of …

Despite the common use of thrombolytic drugs, especially in stroke treatment, there are
many conflicting studies on factors affecting fibrinolysis. Because of the complexity of the …

Proteolytic degradation of fibrin, the major structural component in blood clots, is critical both
during normal wound healing and in the treatment of ischemic stroke and myocardial …

The earliest assessment of fibrin network porosity used a liquid permeation system and
confocal 3D microscopy, which was later replaced by scanning electron microscopy …

Abnormal fibrin architecture is thought to be a determinant factor of hypofibrinolysis.
However, because of the lack of structural knowledge of the process of fibrin digestion …

One of the routine clinical treatments to eliminate ischemic stroke thrombi is injecting a
biochemical product into the patient's bloodstream, which breaks down the thrombi's fibrin …

The enzymatic degradation of blood clots, fibrinolysis, is an important part of a healthy
hemostatic system. If intrinsic fibrinolysis is ineffective, thrombolysis—the clinically-induced …

Fibrin plays a fundamentally important role during hemostasis. To withstand the shear forces
of blood flow and prevent embolisation, fibrin monomers form a three-dimensional polymer …