Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions

GM Lucas, RE Chaisson, RD Moore - Annals of internal medicine, 1999 - acpjournals.org
Background: In clinical trials, highly active antiretroviral therapy (HAART) reduces plasma
HIV-1 RNA levels to less than 500 copies/mL in 60% to 90% of patients with HIV-1 infection …

Human immunodeficiency virus 1 protease inhibitors in clinical practice: predictors of virological outcome

H Valdez, MM Lederman, I Woolley… - Archives of Internal …, 1999 - jamanetwork.com
Objectives To ascertain whether prolonged suppression of viral replication can be achieved
in clinical practice and to identify factors associated with virological outcome. Design …

Virologic outcome and predictors of virologic failure of highly active antiretroviral therapy containing protease inhibitors

H Knobel, A Guelar, A Carmona, M Espona… - AIDS Patient Care …, 2001 - liebertpub.com
In this observational single-center cohort study outside the clinical trial setting, outcome and
predictors of virologic failure of highly active antiretroviral therapy (HAART) containing a …

Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease

EL Murphy, AC Collier, LA Kalish… - Annals of internal …, 2001 - acpjournals.org
Background: Mortality and morbidity related to AIDS have decreased among HIV-infected
patients taking highly active anti-retroviral therapy (HAART), but previous studies may have …

Outcome and predictors of failure of highly active antiretroviral therapy: one-year follow-up of a cohort of human immunodeficiency virus type 1-infected persons

FWNM Wit, R Van Leeuwen… - The Journal of …, 1999 - academic.oup.com
The outcome and predictors of virologic treatment failure of highly active antiretroviral
therapy (HAART) were determined for 271 human immunodeficiency virus (HIV)-infected …

Adherence to protease inhibitor therapy and outcomes in patients with HIV infection

DL Paterson, S Swindells, J Mohr, M Brester… - Annals of internal …, 2000 - acpjournals.org
Background: Combination antiretroviral therapy with protease inhibitors has transformed HIV
infection from a terminal condition into one that is manageable. However, the complexity of …

Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents

AS Fauci, JG Bartlett, EP Goosby… - Annals of internal …, 1998 - researchwithrutgers.com
The availability of an increasing number of antiretroviral agents and the rapid evolution of
new information has introduced extraordinary complexity into the treatment of HIV-infected …

The case for more cautious, patient-focused antiretroviral therapy

K Henry - Annals of internal medicine, 2000 - acpjournals.org
Many clinicians who care for patients with HIV infection are dissatisfied with the existing
recommendations on antiretroviral therapy. Current practice focuses on the early …

Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure

WA O'Brien, PM Hartigan, ES Daar… - Annals of internal …, 1997 - acpjournals.org
Background: Markers are needed for assessing response to antiretroviral therapy over time.
The CD4+ lymphocyte count is one such surrogate, but it is relatively weak. Objective: To …

The changing incidence of AIDS events in patients receiving highly active antiretroviral therapy

Antiretroviral Therapy Cohort … - Archives of internal …, 2005 - jamanetwork.com
Background Although the incidence of most AIDS events declines after initiation of highly
active antiretroviral therapy (HAART), this decline is more rapid for some conditions than …