[HTML][HTML] LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis
GATA-1-dependent transcription is essential for erythroid differentiation and maturation.
Suppression of programmed cell death is also thought to be critical for this process; …
Suppression of programmed cell death is also thought to be critical for this process; …
GATA-1 and Gfi-1B Interplay To Regulate Bcl-xL Transcription
YY Kuo, ZF Chang - Molecular and cellular biology, 2007 - Taylor & Francis
The induction of Bcl-xL is critical for the survival of late proerythroblasts. The erythroid-
specific transcriptional network that regulates Bcl-xL expression in erythropoiesis remains …
specific transcriptional network that regulates Bcl-xL expression in erythropoiesis remains …
GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression
T Gregory, C Yu, A Ma, SH Orkin… - Blood, The Journal …, 1999 - ashpublications.org
The transcription factor GATA-1 is essential for normal erythropoiesis. By examining in vitro–
differentiated embryonic stem cells, we showed previously that in the absence of GATA-1 …
differentiated embryonic stem cells, we showed previously that in the absence of GATA-1 …
[HTML][HTML] Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis
How cell proliferation subsides as cells terminally differentiate remains largely enigmatic,
although this phenomenon is central to the existence of multicellular organisms. Here, we …
although this phenomenon is central to the existence of multicellular organisms. Here, we …
Regulation of GATA1 levels in erythropoiesis
L Gutiérrez, N Caballero, L Fernández‐Calleja… - IUBMB …, 2020 - Wiley Online Library
GATA1 is considered as the “master” transcription factor in erythropoiesis. It regulates at the
transcriptional level all aspects of erythroid maturation and function, as revealed by gene …
transcriptional level all aspects of erythroid maturation and function, as revealed by gene …
[HTML][HTML] A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation
T Moriguchi, M Yamamoto - International journal of hematology, 2014 - Springer
GATA transcription factor family members GATA1 and GATA2 play crucial roles in the
regulation of lineage-restricted genes during erythroid differentiation. GATA1 is …
regulation of lineage-restricted genes during erythroid differentiation. GATA1 is …
Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation
RT Doty, X Yan, C Lausted, AD Munday… - Blood, The Journal …, 2019 - ashpublications.org
Erythropoiesis is the complex, dynamic, and tightly regulated process that generates all
mature red blood cells. To understand this process, we mapped the developmental …
mature red blood cells. To understand this process, we mapped the developmental …
[HTML][HTML] Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as
an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability …
an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability …
Global regulation of erythroid gene expression by transcription factor GATA-1
JJ Welch, JA Watts, CR Vakoc, Y Yao, H Wang… - Blood, 2004 - ashpublications.org
Transcription factor GATA-1 is required for erythropoiesis, yet its full actions are unknown.
We performed transcriptome analysis of G1E-ER4 cells, a GATA-1–null erythroblast line that …
We performed transcriptome analysis of G1E-ER4 cells, a GATA-1–null erythroblast line that …
[HTML][HTML] Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors
X Pan, O Ohneda, K Ohneda, F Lindeboom… - Journal of Biological …, 2005 - ASBMB
Transcription factor GATA-1 plays an important role in gene regulation during the
development of erythroid cells. Several reports suggest that GATA-1 plays multiple roles in …
development of erythroid cells. Several reports suggest that GATA-1 plays multiple roles in …