Abstract Alkaline phosphatases (APs, EC 3.1. 3.1) belong to a superfamily of biological
macromolecules that dephosphorylate many phosphometabolites and phosphoproteins and …

Many epithelial cancers overexpress the inducible cyclooxygenase-2 COX-2, which is
thought to be the cause of NSAIDs' antitumor effects. While ketoprofens (Ket) are well-known …

Administration of current non-steroidal anti-inflammatory drugs is often associated with
serious adverse effects. Therefore, there is a constant need to develop new molecules with …

Aspirin (Asp) is one of the most important and ancient member of nonsteroidal anti-
inflammatory drugs (NSAID), commonly used in medication of fever, pain and inflammation …

Cyclooxygenase (COX), is an enzyme that is responsible for the formation of prostanoids,
including thromboxane and prostaglandins. Prostaglandins promote inflammation. Blockage …

Inflammation is a fundamental physiological process that is essential for survival of human
being but at the same time is one of the major causes of human morbidity and mortality. In …

To explore the structure-property relationship in a set of molecules against Cyclooxygenase-
2 (COX-2), pharmacophore modeling, molecular docking and 3D-QSAR studies were …

Cyclooxygenase‐2 (COX‐2) is a key enzyme involved in overexpression in several human
cancerous diseases including breast cancer. By performing efficient virtual screening in a …

Aspirin is part of a group of medications called nonsteroidal anti-inflammatory drugs
(NSAIDs), but differs from most other NSAIDs in the mechanism of action. cyclooxygenases I …

Inflammation plays a pivotal role in all stages of atherosclerosis and therefore targeting the
key enzymes of this pathway may help in ameliorating the disease progression. The current …