Exploring the triple interaction between the host genome, the epigenome, and the gut microbiome in type 1 diabetes

DA Elhag, M Kumar, S Al Khodor - International journal of molecular …, 2020 - mdpi.com
Type 1 diabetes (T1D) is an auto-immune disorder characterized by a complex interaction
between the host immune system and various environmental factors in genetically …

Gut microbiome in type 1 diabetes: A comprehensive review

P Zheng, Z Li, Z Zhou - Diabetes/metabolism research and …, 2018 - Wiley Online Library
Summary Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the
destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In …

Evaluating the causal role of gut microbiota in type 1 diabetes and its possible pathogenic mechanisms

H Zhou, L Sun, S Zhang, X Zhao, X Gang… - Frontiers in …, 2020 - frontiersin.org
Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic,
epigenetic, and environmental factors. In recent years, the emergence of high-throughput …

Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

JA Mullaney, JE Stephens, ME Costello, C Fong… - Microbiome, 2018 - Springer
Background Dysbiosis of the gut microbiota has been implicated in the pathogenesis of
many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether …

[PDF][PDF] Gut microbiota and immunopathogenesis of diabetes mellitus type 1 and 2

F Wang, C Zhang, Q Zeng - Front Biosci, 2016 - article.imrpress.com
Diabetes mellitus (DM) is a major increasing global health burden in the aging population.
Understanding the etiology of DM is beneficial for its prevention as well as treatment. In light …

[HTML][HTML] Type 1 diabetes: Through the lens of human genome and metagenome interplay

SZ Vahed, HM Sani, YR Saadat, A Barzegari… - Biomedicine & …, 2018 - Elsevier
Diabetes is a genetic-and epigenetic-related disease from which a large population
worldwide suffers. Some genetic factors along with various mutations related to the immune …

Predicting the role of the human gut microbiome in type 1 diabetes using machine-learning methods

XW Liu, HL Li, CY Ma, TY Shi, TY Wang… - Briefings in …, 2024 - academic.oup.com
Gut microbes is a crucial factor in the pathogenesis of type 1 diabetes (T1D). However, it is
still unclear which gut microbiota are the key factors affecting T1D and their influence on the …

Gut bacterial characteristics of patients with type 2 diabetes mellitus and the application potential

Y Que, M Cao, J He, Q Zhang, Q Chen, C Yan… - Frontiers in …, 2021 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is a complex disorder comprehensively influenced by
genetic and environmental risk, and research increasingly has indicated the role of microbial …

The intestinal microbiome in type 1 diabetes

JL Dunne, EW Triplett, D Gevers… - Clinical & …, 2014 - academic.oup.com
Few concepts in recent years have garnered more disease research attention than that of
the intestinal (ie 'gut') microbiome. This emerging interest has included investigations of the …

Gut microbiome in type 1 diabetes: the immunological perspective

E Rampanelli, M Nieuwdorp - Expert Review of Clinical …, 2023 - Taylor & Francis
ABSTRACT Introduction Type 1 diabetes (T1D) is a prevalent, and yet uncurable,
autoimmune disease targeting insulin-producing pancreatic β-cells. Despite a known …