Cyclodextrin-based metal-organic frameworks for pulmonary delivery of curcumin with improved solubility and fine aerodynamic performance

Y Zhou, Y Zhao, B Niu, Q Luo, Y Zhang, G Quan… - International Journal of …, 2020 - Elsevier
Pulmonary drug delivery has attracted considerable attention in recent years. However, it is
still a major challenge to deliver poorly water-soluble drugs to lungs with good solubility and …

[HTML][HTML] γ-Cyclodextrin metal-organic frameworks as the promising carrier for pulmonary delivery of cyclosporine A

Y Huang, H Tang, X Meng, D Liu, Y Liu, B Chen… - Biomedicine & …, 2024 - Elsevier
Abstract γ-Cyclodextrin metal-organic frameworks (CD-MOFs) are considered as a green
and biocompatible material with great potential in drug delivery systems. Original CD-MOFs …

Cyclodextrin-based metal–organic framework nanoparticles as superior carriers for curcumin: Study of encapsulation mechanism, solubility, release kinetics, and …

Y Chen, J Su, W Dong, D Xu, L Cheng, L Mao, Y Gao… - Food Chemistry, 2022 - Elsevier
In this paper, we propose a facile program of preparing nanoscale γ-cyclodextrin-based
metal–organic frameworks (Nano-CD-MOFs) for the encapsulation of curcumin. Such Nano …

[HTML][HTML] A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility

Y Zhou, B Niu, B Wu, S Luo, J Fu, Y Zhao… - … Pharmaceutica Sinica B, 2020 - Elsevier
Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous
particles can effectively enhance the aerosolization performance and bioavailability of …

Novel γ-cyclodextrin-metal–organic frameworks for encapsulation of curcumin with improved loading capacity, physicochemical stability and controlled release …

Y Chen, K Tai, P Ma, J Su, W Dong, Y Gao, L Mao… - Food Chemistry, 2021 - Elsevier
A safe and biodegradable γ-cyclodextrin-metal–organic-frameworks (γ-CD-MOFs) was
successfully synthesized by using an improved hydrothermal method. In this study, curcumin …

Simultaneous solubilization and extended release of insoluble drug as payload in highly soluble particles of γ-cyclodextrin metal-organic frameworks

Y Liu, P Zhou, Z Cao, W Liang, J Yan, H Xu… - International Journal of …, 2022 - Elsevier
The inclusion and nanocluster formed in cyclodextrin-metal organic framework (CD-MOF)
make it a remarkable vehicle in improving the solubility and bioavailability of insoluble …

Pulmonary targeting crosslinked cyclodextrin metal–organic frameworks for lung cancer therapy

Y He, T Xiong, S He, H Sun, C Huang… - Advanced Functional …, 2021 - Wiley Online Library
Lung cancer is a serious threat to human health with the highest morbidity and mortality;
metastatic lung cancer accounts for a majority of cancer‐related deaths. Hence, there is …

[HTML][HTML] Allyl isothiocyanate dry powder inhaler based on cyclodextrin-metal organic frameworks for pulmonary delivery

N Sun, M Zhang, W Zhu, P Song, T Dai, P Huang… - Iscience, 2023 - cell.com
In this study, allyl isothiocyanate (AITC) was prepared as the dry powder inhalation by
loading cyclodextrin metal-organic framework (CD-MOF) to enhance pulmonary delivery. β …

Solidification of volatile D-Limonene by cyclodextrin metal-organic framework for pulmonary delivery via dry powder inhalers: In vitro and in vivo evaluation

Y Zhou, M Zhang, C Wang, X Ren, T Guo, Z Cao… - International Journal of …, 2021 - Elsevier
Abstract D-Limonene (D-Lim), a volatile oil extracted from citrus fruits, has therapeutic effects
on lung inflammation and cancer, whilst the deep delivery of D-Lim was challenging due to …

Facile Synthesis and Size Control of 2D Cyclodextrin‐Based Metal–Organic Frameworks Nanosheet for Topical Drug Delivery

MG Bello, Y Yang, C Wang, L Wu… - Particle & Particle …, 2020 - Wiley Online Library
In this work, a 2D nanosheet (NS) of γ‐cyclodextrin (CD)‐based metal–organic frameworks
(MOFs) is synthesized through a facile green chemistry approach. NS‐MOF carrier is …