Targeted protein degradation is a pharmacological modality that is based on the induced
proximity of an E3 ubiquitin ligase and a target protein to promote target ubiquitination and …

Small molecules that induce protein-protein interactions to exert proximity-driven
pharmacology such as targeted protein degradation are a powerful class of therapeutics 1 …

Heterobifunctional small-molecule degraders that induce protein degradation through ligase-
mediated ubiquitination have shown considerable promise as a new pharmacological …

Targeted protein degradation with monovalent molecular glue degraders is a powerful
therapeutic modality for eliminating disease causing proteins. However, rational design of …

Targeted protein degradation relies on small molecules that induce new protein–protein
interactions between targets and the cellular protein degradation machinery. Most of these …

Small molecules that can induce protein degradation by inducing proximity between a
desired target and an E3 ligase have the potential to greatly expand the number of proteins …

Targeted protein degradation is mediated by small molecules that induce or stabilize protein–
protein interactions between targets and the ubiquitin–proteasome machinery. Currently …

Inducing macromolecular interactions with small molecules to activate cellular signaling is a
challenging goal. PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that …

Proteolysis targeting chimeras are bifunctional small molecules capable of recruiting a target
protein of interest to an E3 ubiquitin ligase that facilitates target ubiquitination followed by …

Engineered destruction of target proteins by recruitment to the cell's degradation machinery
has emerged as a promising strategy in drug discovery. The majority of molecules that …