[HTML][HTML] Protein-Protein interactions uncover candidate 'core genes' within omnigenic disease networks
Genome wide association studies (GWAS) of human diseases have generally identified
many loci associated with risk with relatively small effect sizes. The omnigenic model …
many loci associated with risk with relatively small effect sizes. The omnigenic model …
Combining SNP-to-gene linking strategies to pinpoint disease genes and assess disease omnigenicity
Although genome-wide association studies (GWAS) have identified thousands of disease-
associated common SNPs, these SNPs generally do not implicate the underlying target …
associated common SNPs, these SNPs generally do not implicate the underlying target …
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate
target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking …
target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking …
[HTML][HTML] Network properties of complex human disease genes identified through genome-wide association studies
Background Previous studies of network properties of human disease genes have mainly
focused on monogenic diseases or cancers and have suffered from discovery bias. Here we …
focused on monogenic diseases or cancers and have suffered from discovery bias. Here we …
Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases
Background While genome-wide association studies (GWAS) of complex traits have
revealed thousands of reproducible genetic associations to date, these loci collectively …
revealed thousands of reproducible genetic associations to date, these loci collectively …
ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations
ER Chimusa, M Mbiyavanga, GK Mazandu… - …, 2016 - academic.oup.com
Abstract Motivation: Despite numerous successful Genome-wide Association Studies
(GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may …
(GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may …
Linking disease associations with regulatory information in the human genome
Genome-wide association studies have been successful in identifying single nucleotide
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
Systems-level analysis of genome-wide association data
CR Farber - G3: Genes| Genomes| Genetics, 2013 - academic.oup.com
Genome-wide association studies (GWAS) have emerged as the method of choice for
identifying common variants affecting complex disease. In a GWAS, particular attention is …
identifying common variants affecting complex disease. In a GWAS, particular attention is …
[HTML][HTML] Joint GWAS analysis: comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases
MJ McGeachie, GL Clemmer, J Lasky-Su, A Dahlin… - Genomics data, 2014 - Elsevier
We show here that combining two existing genome wide association studies (GWAS) yields
additional biologically relevant information, beyond that obtained by either GWAS …
additional biologically relevant information, beyond that obtained by either GWAS …
Post genome-wide association analysis: dissecting computational pathway/network-based approaches
Over thousands of genetic associations to diseases have been identified by genome-wide
association studies (GWASs), which conceptually is a single-marker-based approach. There …
association studies (GWASs), which conceptually is a single-marker-based approach. There …