Mitochondrial function in spinal cord injury and regeneration
PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …
[HTML][HTML] Targeting mitochondrial function for the treatment of acute spinal cord injury
ML McEwen, PG Sullivan, AG Rabchevsky… - …, 2011 - Elsevier
Traumatic injury to the mammalian spinal cord is a highly dynamic process characterized by
a complex pattern of pervasive and destructive biochemical and pathophysiological events …
a complex pattern of pervasive and destructive biochemical and pathophysiological events …
Mitochondria focused neurotherapeutics for spinal cord injury
AG Rabchevsky, FM Michael, SP Patel - Experimental neurology, 2020 - Elsevier
The mitochondrion is a double membrane structured organelle involved in a variety of
regulatory functions such as calcium signaling, production of adenosine triphosphate …
regulatory functions such as calcium signaling, production of adenosine triphosphate …
Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target
NE Scholpa, RG Schnellmann - Journal of Pharmacology and Experimental …, 2017 - ASPET
Spinal cord injury (SCI) is characterized by an initial trauma followed by a progressive
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …
Mitochondrial behavior in axon degeneration and regeneration
B Wang, M Huang, D Shang, X Yan, B Zhao… - Frontiers in Aging …, 2021 - frontiersin.org
Mitochondria are organelles responsible for bioenergetic metabolism, calcium homeostasis,
and signal transmission essential for neurons due to their high energy consumption …
and signal transmission essential for neurons due to their high energy consumption …
Mitochondria as a central sensor for axonal degenerative stimuli
MP Coleman - Trends in neurosciences, 2012 - cell.com
Axonal degeneration is a major contributor to neuronal dysfunction in many neurological
conditions and has additional roles in development. It can be triggered by divergent stimuli …
conditions and has additional roles in development. It can be triggered by divergent stimuli …
Mitochondrial transplantation attenuates neural damage and improves locomotor function after traumatic spinal cord injury in rats
MW Lin, SY Fang, JYC Hsu, CY Huang… - Frontiers in …, 2022 - frontiersin.org
Mitochondrial dysfunction is a hallmark of secondary neuroinflammatory responses and
neuronal death in spinal cord injury (SCI). Even though mitochondria-based therapy is an …
neuronal death in spinal cord injury (SCI). Even though mitochondria-based therapy is an …
Human umbilical cord-derived mesenchymal stem cells-harvested mitochondrial transplantation improved motor function in TBI models through rescuing neuronal …
Each year, traumatic brain injury (TBI) causes a high rate of mortality throughout the world
and those who survive have lasting disabilities. Given that the brain is a particularly dynamic …
and those who survive have lasting disabilities. Given that the brain is a particularly dynamic …
Mitochondrial behavior during axon regeneration/degeneration in vivo
S Kiryu-Seo, H Kiyama - Neuroscience research, 2019 - Elsevier
Over the last decade, mitochondrial dynamics beyond function during axon regeneration/
degeneration have received attention. Axons have an effective delivery system of …
degeneration have received attention. Axons have an effective delivery system of …
Novel therapeutic strategies targeting mitochondria as a gateway in neurodegeneration
D Trigo, JJ Vitória, OABC e Silva - Neural Regeneration Research, 2023 - journals.lww.com
In recent years, multiple disciplines have focused on mitochondrial biology and contributed
to understanding its relevance towards adult-onset neurodegenerative disorders. These are …
to understanding its relevance towards adult-onset neurodegenerative disorders. These are …