High-throughput genotyping has enabled discovery of genetic variants associated with an
increased risk of developing prostate cancer using genome-wide association studies …

Background Recent advances in high-throughput genotyping have made possible
identification of genetic variants associated with increased risk of developing prostate …

Genome-wide association studies (GWAS) have achieved great success in identifying single
nucleotide polymorphisms (SNPs, herein called genetic variants) and genes associated with …

Understanding the functional role of risk regions identified by genome-wide association
studies (GWAS) has made considerable recent progress and is referred to as the post …

Background Genome-wide association studies (GWASs) and global profiling of gene
expression (microarrays) are two major technological breakthroughs that allow hypothesis …

Background Pathway analysis of large-scale omics data assists us with the examination of
the cumulative effects of multiple functionally related genes, which are difficult to detect …

Abstract Background Prostate cancer (PCa) is the most common diagnosed malignancy and
the second leading cause of cancer-related deaths among men in the United States. High …

Prostate cancer is the most common cancer in men in Europe and the United States. The
genetic heritability of prostate cancer is contributed to by both rarely occurring genetic …

Background. Majority of prostate cancer (PCa) deaths are attributed to localized high‐grade
aggressive tumours which progress rapidly to metastatic disease. A critical unmet need in …

Genome-wide association studies (GWAS) have been successful in deciphering the genetic
component of predisposition to many human complex diseases including prostate cancer …