The role of molecular imaging in modern drug development
L Cunha, K Szigeti, D Mathé, LF Metello - Drug Discovery Today, 2014 - Elsevier
Highlights•Molecular imaging improves drug development efficiency and shortens
timings.•Molecular imaging can play an important part most phases of drug …
timings.•Molecular imaging can play an important part most phases of drug …
Molecular imaging in drug discovery and development
M Rudin, R Weissleder - Nature reviews Drug discovery, 2003 - nature.com
Imaging sciences have grown exponentially during the past three decades, and many
techniques, such as magnetic resonance imaging, nuclear tomographic imaging and X-ray …
techniques, such as magnetic resonance imaging, nuclear tomographic imaging and X-ray …
Applications of molecular imaging in drug discovery and development process
BC Ahn - Current Pharmaceutical Biotechnology, 2011 - ingentaconnect.com
The process of drug discovery and development requires enormous resources and time,
with increasing cost for new drug development. Molecular imaging techniques have …
with increasing cost for new drug development. Molecular imaging techniques have …
Accelerating drug discovery and development through in vivo imaging
WC Eckelman - Nuclear medicine and biology, 2002 - Elsevier
In order to accelerate the drug discovery process and to increase the annual number of
approved drugs, pharmaceutical chemists have developed new procedures, such as …
approved drugs, pharmaceutical chemists have developed new procedures, such as …
Technologies: preclinical imaging for drug development
Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography
(CT), ultrasound (US), positron emission tomography (PET) or single-photon emission …
(CT), ultrasound (US), positron emission tomography (PET) or single-photon emission …
Molecular imaging in drug development
JK Willmann, N Van Bruggen, LM Dinkelborg… - Nature reviews Drug …, 2008 - nature.com
Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …
processes in living subjects. Such technologies therefore have the potential to enhance our …
Noninvasive structural, functional, and molecular imaging in drug development
M Rudin - Current opinion in chemical biology, 2009 - Elsevier
Modern drug research is mechanism-based and the development of disease modifying
therapies involves the identification of molecular key players in the pathological cascade …
therapies involves the identification of molecular key players in the pathological cascade …
Multimodality imaging: novel pharmacological applications of reporter systems
A Stell, S Belcredito, B Ramachandran… - The Quarterly Journal …, 2007 - search.proquest.com
The development of novel drugs is a lengthy process requiring years of preclinical research
and many steps indispensable to ensure that the molecule of interest can be administered to …
and many steps indispensable to ensure that the molecule of interest can be administered to …
Has molecular and cellular imaging enhanced drug discovery and drug development?
A great many efforts have been made to accelerate the drug discovery and development
process, which is extremely time and money consuming. Recently developed molecular …
process, which is extremely time and money consuming. Recently developed molecular …
The role of molecular imaging in drug discovery and development
RJ Hargreaves - Clinical Pharmacology & Therapeutics, 2008 - Wiley Online Library
Molecular imaging biomarkers are playing an increasingly important role in efforts to
increase the probability of success of drug candidates by helping to validate novel drug …
increase the probability of success of drug candidates by helping to validate novel drug …