The role of molecular imaging in modern drug development

L Cunha, K Szigeti, D Mathé, LF Metello - Drug Discovery Today, 2014 - Elsevier
Highlights•Molecular imaging improves drug development efficiency and shortens
timings.•Molecular imaging can play an important part most phases of drug …

Molecular imaging in drug discovery and development

M Rudin, R Weissleder - Nature reviews Drug discovery, 2003 - nature.com
Imaging sciences have grown exponentially during the past three decades, and many
techniques, such as magnetic resonance imaging, nuclear tomographic imaging and X-ray …

Applications of molecular imaging in drug discovery and development process

BC Ahn - Current Pharmaceutical Biotechnology, 2011 - ingentaconnect.com
The process of drug discovery and development requires enormous resources and time,
with increasing cost for new drug development. Molecular imaging techniques have …

Accelerating drug discovery and development through in vivo imaging

WC Eckelman - Nuclear medicine and biology, 2002 - Elsevier
In order to accelerate the drug discovery process and to increase the annual number of
approved drugs, pharmaceutical chemists have developed new procedures, such as …

Technologies: preclinical imaging for drug development

PM Matthews, R Coatney, H Alsaid, B Jucker… - Drug Discovery Today …, 2013 - Elsevier
Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography
(CT), ultrasound (US), positron emission tomography (PET) or single-photon emission …

Molecular imaging in drug development

JK Willmann, N Van Bruggen, LM Dinkelborg… - Nature reviews Drug …, 2008 - nature.com
Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …

Noninvasive structural, functional, and molecular imaging in drug development

M Rudin - Current opinion in chemical biology, 2009 - Elsevier
Modern drug research is mechanism-based and the development of disease modifying
therapies involves the identification of molecular key players in the pathological cascade …

Multimodality imaging: novel pharmacological applications of reporter systems

A Stell, S Belcredito, B Ramachandran… - The Quarterly Journal …, 2007 - search.proquest.com
The development of novel drugs is a lengthy process requiring years of preclinical research
and many steps indispensable to ensure that the molecule of interest can be administered to …

Has molecular and cellular imaging enhanced drug discovery and drug development?

G Niu, X Chen - Drugs in R & D, 2008 - Springer
A great many efforts have been made to accelerate the drug discovery and development
process, which is extremely time and money consuming. Recently developed molecular …

The role of molecular imaging in drug discovery and development

RJ Hargreaves - Clinical Pharmacology & Therapeutics, 2008 - Wiley Online Library
Molecular imaging biomarkers are playing an increasingly important role in efforts to
increase the probability of success of drug candidates by helping to validate novel drug …