DYX1C1 has been associated with dyslexia and neuronal migration in the developing
neocortex. Unexpectedly, we found that deleting exons 2–4 of Dyx1c1 in mice caused a …

Primary ciliary dyskinesia most often arises from loss of the dynein motors that power ciliary
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …

DYX1C1, a susceptibility gene for dyslexia, encodes a tetratricopeptide repeat domain
containing protein that has been implicated in neuronal migration in rodent models. The …

Primary ciliary dyskinesia (PCD) is a recessively inherited disease that leads to chronic
respiratory disorders owing to impaired mucociliary clearance. Conventional transmission …

By moving essential body fluids and molecules, motile cilia and flagella govern respiratory
mucociliary clearance, laterality determination and the transport of gametes and …

Motile cilia move body fluids and gametes and the beating of cilia lining the airway epithelial
surfaces ensures that they are kept clear and protected from inhaled pathogens and …

Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic
airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients …

Primary ciliary dyskinesia (PCD) is a ciliopathy characterized by airway disease, infertility,
and laterality defects, often caused by dual loss of the inner dynein arms (IDAs) and outer …

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by
chronic destructive airway disease and randomization of left/right body asymmetry. Males …

Dysfunction of motile monocilia, altering the leftward flow at the embryonic node essential for
determination of left-right body asymmetry, is a major cause of laterality defects. Laterality …