With the wide spread of multidrug-resistant bacteria, a variety of aminoglycosides have been
used in clinical practice as one of the effective options for antimicrobial combinations …

Exogenously acquired 16S rRNA methyltransferase (16S-RMTase) genes responsible for a
very high level of resistance against various aminoglycosides have been widely distributed …

(Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter
baumannii, Pseudomonas aeruginosa, and Enterobacter spp) pathogens, has become a …

The methylation of a ribosomal target leads to a high level of resistance to all clinically
relevant aminoglycoside antibiotics, so early detection of these resistance determinants will …

Background The resistance to all aminoglycosides (AGs) conferred by 16S rRNA
methyltransferase enzymes (16S-RMTases) is a major public health concern. Objectives To …

Objectives The prevalence of genes encoding aminoglycoside-modifying enzymes (AMEs)
and 16S rRNA methyltransferases among 200 Gram-negative clinical isolates resistant to …

Production of 16S rRNA methylase has recently drawn attention as a novel aminoglycoside
resistance mechanism in pathogenic gram-negative bacteria (1). It confers very-highlevel …

The acquisition of multidrug resistance in nosocomial pathogens such as Serratia
marcescens has been reported in the absence of antibiotic selection pressure. The broad …

Antimicrobial resistance has been recognized as one of the most pressing public health and
societal issues of our times. The problem is most acute in gram-negative bacteria, where …

Methylation of 16S ribosomal RNA (rRNA) has recently emerged as a new mechanism of
resistance against aminoglycosides among gram-negative pathogens belonging to the …