Instrumentation for vibrational circular dichroism spectroscopy: method comparison and newer developments

TA Keiderling - Molecules, 2018 - mdpi.com
Vibrational circular dichroism (VCD) is a widely used standard method for determination of
absolute stereochemistry, and somewhat less so for biomolecule characterization and …

Vibrational circular dichroism: an incisive tool for stereochemical applications.

LA Nafie, TB Freedman - Enantiomer, 1998 - europepmc.org
Vibrational circular dichroism (VCD) is the extension of circular dichroism (CD) from
electronic to vibrational transitions in molecules. In this review, we present the basic …

Mini review: Instrumentation for vibrational circular dichroism spectroscopy, still a role for dispersive instruments

TA Keiderling, A Lakhani - Chirality, 2018 - Wiley Online Library
Vibrational circular dichroism (VCD) has become a standard method for determination of
absolute stereochemistry, particularly now that reliable commercial instrumentation has …

Taming conformational heterogeneity in and with vibrational circular dichroism spectroscopy

MAJ Koenis, Y Xia, SR Domingos, L Visscher… - Chemical …, 2019 - pubs.rsc.org
The flexibility of a molecule has important consequences on its function and application.
Vibrational Circular Dichroism (VCD) is intrinsically an excellent experimental technique to …

Absolute configuration determination of chiral molecules in the solution state using vibrational circular dichroism

TB Freedman, X Cao, RK Dukor, LA Nafie - Chirality, 2003 - Wiley Online Library
Advances in the measurement, calculation, and application of vibrational circular dichroism
(VCD) for the determination of absolute configuration are described. The purpose of the …

Determination of Absolute Stereochemistry of Flexible Molecules Using a Vibrational circular dichroism spectra alignment algorithm

L Böselt, D Sidler, T Kittelmann… - Journal of chemical …, 2019 - ACS Publications
Experimental determination of the absolute stereochemistry of chiral molecules has been a
fundamental challenge in natural sciences for decades. Vibrational circular dichroism (VCD) …

[PDF][PDF] Vibrational circular dichroism spectroscopy: A new tool for the stereochemical characterization of chiral molecules

PJ Stephens - Chapter, 2004 - ndl.ethernet.edu.et
Pharmaceutical compounds—drugs—are generally small to medium-sized organic
molecules. Many are chiral. When this is the case, either a pure enantiomer or a racemic …

Vibrational circular dichroism

G Magyarfalvi, G Tarczay, E Vass - Wiley Interdisciplinary …, 2011 - Wiley Online Library
This review focuses on the theoretical background of vibrational circular dichroism (VCD)
spectroscopy. Besides discussing the first‐principle approaches of the theoretical evaluation …

On the Complementarity of ECD and VCD Techniques

VP Nicu, A Mándi, T Kurtán, PL Polavarapu - Chirality, 2014 - Wiley Online Library
An unprecedented complementarity of electronic circular dichroism (ECD) and vibrational
circular dichroism (VCD) spectroscopic techniques is demonstrated by showing that each …

Vibrational circular dichroism: a new spectroscopic tool for biomolecular structural determination

PL Polavarapu, C Zhao - Fresenius' journal of analytical chemistry, 2000 - Springer
Vibrational circular dichroism (VCD) in the past two decades has developed into a powerful
new structural tool. A concise review of the applications of VCD to determine the structures …