Acinetobacter baumannii is an opportunistic pathogen and an emerging global health threat.
Within healthcare settings, major presentations of A. baumannii include bloodstream …

Available antibiotics to treat Acinetobacter baumannii infection is limited due to increasing
resistance and the emergence of multiple drug-resistant strains. Hence, discovering effective …

Lipocalin 2 (Lcn2) is an essential component of the antimicrobial innate immune system. It
attenuates bacterial growth by binding and sequestering the iron-scavenging siderophores …

Competition for iron is a critical component of successful bacterial infections, but the
underlying in vivo mechanisms are poorly understood. We have previously demonstrated …

Background Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin,
an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial …

Pulmonary tuberculosis (TB), caused by the intracellular bacteria Mycobacterium
tuberculosis, is a worldwide disease that continues to kill more than 1.5 million people every …

Lipocalin-2 (LCN2) is an inflammatory mediator best known for its role as an innate acute-
phase protein. LCN2 mediates the innate immune response to pathogens by sequestering …

Mycobacterium tuberculosis invades alveolar epithelial cells as well as macrophages.
However, the role of alveolar epithelial cells in the host defense against M. tuberculosis …

Abstract Lipocalin 2 (Lcn2) is an important innate immunity component against bacterial
pathogens. In this study, we report that Lcn2 is induced by Brucella (B.) abortus infection and …

Nasal colonization by both gram-positive and gram-negative pathogens induces expression
of the innate immune protein lipocalin 2 (Lcn2). Lcn2 binds and sequesters the iron …